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Use Chou's 5-steps rule to study how Baicalin suppresses the malignant phenotypes and induces the apoptosis of colorectal cancer cells.

Archives of biochemistry and biophysics - 15 Jul 2021

Zhang Wei, Liu Quanlin, Luo Linshan, Song Jingfeng, Han Keshun, Liu Ruitao, Gong Yuesheng, Guo Xiaoran

Abstract excerpt

Baicalin is a traditional Chinese herb purified from the root of Scutellaria baicalensis Georgi. In this study, we further analyzed the molecular mechanism behind the anti-tumor activity of Baicalin in colorectal cancer (CRC). The establishment of circular RNA (circRNA)/microRNA (miRNA)/messenger RNA (mRNA) axis was predicted by bioinformatic databases and verified by dual-luciferase reporter assay and RNA...

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PMID: 33992597
DOI: 10.1016/j.abb.2021.108919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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