Article
Polygenic Scores for Cognitive Abilities and Their Association with Different Aspects of General Intelligence-A Deep Phenotyping Approach.
Molecular neurobiology - 1 Aug 2021
Genç Erhan, Schlüter Caroline, Fraenz Christoph, Arning Larissa, Metzen Dorothea, Nguyen Huu Phuc, Voelkle Manuel C, Streit Fabian, Güntürkün Onur, Kumsta Robert, Ocklenburg Sebastian
Abstract excerpt
Intelligence is a highly polygenic trait and genome-wide association studies (GWAS) have identified thousands of DNA variants contributing with small effects. Polygenic scores (PGS) can aggregate those effects for trait prediction in independent samples. As large-scale light-phenotyping GWAS operationalized intelligence as performance in rather superficial tests, the question arises which intelligence facets are...
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