Article
A case series highlighting structured hematological, biochemical and molecular approach to clinical oral iron refractoriness in children: A pressing need for a 3-tier system for classification of variants in TMPRSS6 gene.
Blood cells, molecules & diseases - 1 Jul 2021
Sharma Pankaj, Bhatia Prateek, Singh Minu, Das Reena, Jain Richa, Bansal Deepak, Attri Savita Verma, Trehan Amita
Abstract excerpt
In current study, we discuss clinical oral iron refractoriness cases and highlight need for a classification system to define TMPRSS6 gene variants. Out of 231 cases of microcytic hypochromic anemia screened (Sept 2019-Dec 2020), 17 cases (7.35%) with unexplained iron refractoriness (URIDA) phenotype were enrolled after ruling out secondary causes and compliance related issues. 11 (65%) had absent/negligible...
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