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Article

A New Pathogenic Variant in POU3F4 Causing Deafness Due to an Incomplete Partition of the Cochlea Paved the Way for Innovative Surgery.

Genes - 21 Apr 2021

Tekin Ahmet M, Matulic Marco, Wuyts Wim, Assadi Masoud Zoka, Mertens Griet, Rompaey Vincent van, Li Yongxin, Heyning Paul van de, Topsakal Vedat

Abstract excerpt

Incomplete partition type III (IP-III) is a relatively rare inner ear malformation that has been associated with a POU3F4 gene mutation. The IP-III anomaly is mainly characterized by incomplete separation of the modiolus of the cochlea from the internal auditory canal. We describe a 71-year-old woman with profound sensorineural hearing loss diagnosed with an IP-III of the cochlea that underwent cochlear...

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Identifiers

PMID: 33919129
DOI: 10.3390/genes12050613
PMCID: PMC8143104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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