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Article

Allelic polymorphism at foxo contributes to local adaptation in Drosophila melanogaster.

Molecular ecology - 1 Jun 2021

Betancourt Nicolas J, Rajpurohit Subhash, Durmaz Esra, Fabian Daniel K, Kapun Martin, Flatt Thomas, Schmidt Paul

Abstract excerpt

The insulin/insulin-like growth factor signalling pathway has been hypothesized as a major determinant of life-history profiles that vary adaptively in natural populations. In Drosophila melanogaster, multiple components of this pathway vary predictably with latitude; this includes foxo, a conserved gene that regulates insulin signalling and has pleiotropic effects on a variety of fitness-associated traits. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33914989
DOI: 10.1111/mec.15939
PMCID: PMC8693798

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