Article
The long-term genetic stability and individual specificity of the human gut microbiome.
Cell - 29 Apr 2021
Chen Lianmin, Wang Daoming, Garmaeva Sanzhima, Kurilshikov Alexander, Vich Vila Arnau, Gacesa Ranko, Sinha Trishla, Segal Eran, Weersma Rinse K, Wijmenga Cisca, Zhernakova Alexandra, Fu Jingyuan
Abstract excerpt
By following up the gut microbiome, 51 human phenotypes and plasma levels of 1,183 metabolites in 338 individuals after 4 years, we characterize microbial stability and variation in relation to host physiology. Using these individual-specific and temporally stable microbial profiles, including bacterial SNPs and structural variations, we develop a microbial fingerprinting method that shows up to 85% accuracy in...
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