An interplay of resource availability, population size and mutation rate potentiates the evolution of metabolic signaling.

Abstract excerpt

BACKGROUND: Asexually reproducing populations of single cells evolve through mutation, natural selection, and genetic drift. Environmental conditions in which the evolution takes place define the emergent fitness landscapes. In this work, we used Avida-a digital evolution framework-to uncover a hitherto unexplored interaction between mutation rates, population size, and the relative abundance of metabolizable...

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