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Article

The Major Ciliary Isoforms of RPGR Build Different Interaction Complexes with INPP5E and RPGRIP1L.

International journal of molecular sciences - 30 Mar 2021

Vössing Christine, Atigbire Paul, Eilers Jannis, Markus Fenja, Stieger Knut, Song Fei, Neidhardt John

Abstract excerpt

X-linked retinitis pigmentosa (XLRP) is frequently caused by mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene. A complex splicing process acts on the RPGR gene resulting in three major isoforms: RPGRex1-19, RPGRORF15 and RPGRskip14/15. We characterized the widely expressed, alternatively spliced transcript RPGRskip14/15 lacking exons 14 and 15. Using the CRISPR/eSpCas9 system, we generated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33808286
DOI: 10.3390/ijms22073583
PMCID: PMC8037643

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