Article
The Prophage and Plasmid Mobilome as a Likely Driver of Mycobacterium abscessus Diversity.
mBio - 30 Mar 2021
Dedrick Rebekah M, Aull Haley G, Jacobs-Sera Deborah, Garlena Rebecca A, Russell Daniel A, Smith Bailey E, Mahalingam Vaishnavi, Abad Lawrence, Gauthier Christian H, Hatfull Graham F
Abstract excerpt
Mycobacterium abscessus is an emerging pathogen that is often refractory to antibiotic control. Treatment is further complicated by considerable variation among clinical isolates in both their genetic constitution and their clinical manifestations. Here, we show that the prophage and plasmid mobilome is a likely contributor to this variation. Prophages and plasmids are common, abundant, and highly diverse, and...
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