Article
Patient-Reported Outcomes in Patients With PIK3CA-Mutated Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer From SOLAR-1.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Jun 2021
Ciruelos Eva Maria, Rugo Hope S, Mayer Ingrid A, Levy Christelle, Forget Frédéric, Delgado Mingorance Juan Ignacio, Safra Tamar, Masuda Norikazu, Park Yeon Hee, Juric Dejan, Conte Pierfranco, Campone Mario, Loibl Sibylle, Iwata Hiroji, Zhou Xiaolei, Park Jinhee, Ridolfi Antonia, Lorenzo Ines, André Fabrice
Abstract excerpt
PURPOSE: In the phase III SOLAR-1 trial (NCT02437318), the PI3Kα-selective inhibitor and degrader alpelisib significantly improved median progression-free survival when added to fulvestrant in patients with phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA)-mutated, hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer. We assessed...
Topics
Join the communities discussing this publication.