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Article

Secoisolariciresinol diglucoside induces caspase‐3‐mediated apoptosis in monolayer and spheroid cultures of human colon carcinoma cells

29 Mar 2021

Abstract excerpt

Apoptotic effects of secoisolariciresinol diglucoside (SDG) in 2D and 3D cultures of SW480 cells were investigated. 40-200 μM SDG was used and IC50 values were determined for three different time intervals as 24, 48, or 72 hr for further experiments. BrdU, TUNEL, AIF, and caspase-3 stainings were used. SDG inhibited cell proliferation almost half and half for all time intervals in 2D and 3D cultures and also,...

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PMID: 33778961
DOI: 10.1111/jfbc.13719

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