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Impaired Intestinal Barrier and Tissue Bacteria: Pathomechanisms for Metabolic Diseases

9 Mar 2021

Abstract excerpt

An intact intestinal barrier, representing the interface between inner and outer environments, is an integral regulator of health. Among several factors, bacteria and their products have been evidenced to contribute to gut barrier impairment and its increased permeability. Alterations of tight junction integrity - caused by both external factors and host metabolic state - are important for gut barrier, since they...

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PMID: 33767669
DOI: 10.3389/fendo.2021.616506

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