Article
The "Burkitt-like" immunophenotype and genotype is rarely encountered in diffuse large B cell lymphoma and high-grade B cell lymphoma, NOS.
Virchows Archiv : an international journal of pathology - 1 Sept 2021
Hüttl Katrin S, Staiger Annette M, Richter Julia, Ott M Michaela, Kalmbach Sabrina, Klapper Wolfram, Biesdorf Anne-Sophie, Trümper Lorenz, Rosenwald Andreas, Ziepert Marita, Horn Heike, Ott German
Abstract excerpt
Burkitt lymphoma (BL) is a B cell lymphoma composed of monomorphic medium-sized blastic cells with basophilic cytoplasm and a high proliferation index. BL has a characteristic immunophenotype of CD10 and BCL6 positive and BCL2 negative and harbours MYC gene rearrangements (MYCR) in >90% of the cases. Owing to its highly aggressive nature, intensified chemotherapy regimens are usually administered, requiring an...
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