Article
Mapping genetic changes in the cAMP-signaling cascade in human atria.
Journal of molecular and cellular cardiology - 1 Jun 2021
Garnier Anne, Bork Nadja I, Jacquet Eric, Zipfel Svante, Muñoz-Guijosa Christian, Baczkó Istvan, Reichenspurner Hermann, Donzeau-Gouge Patrick, Maier Lars S, Dobrev Dobromir, Girdauskas Evaldas, Nikolaev Viacheslav O, Fischmeister Rodolphe, Molina Cristina E
Abstract excerpt
AIM: To obtain a quantitative expression profile of the main genes involved in the cAMP-signaling cascade in human control atria and in different cardiac pathologies. METHODS AND RESULTS: Expression of 48 target genes playing a relevant role in the cAMP-signaling cascade was assessed by RT-qPCR. 113 samples were obtained from right atrial appendages (RAA) of patients in sinus rhythm (SR) with or without atrium...
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