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Inhibition of Zika virus replication by G-quadruplex-binding ligands

10 Jan 2021

Abstract excerpt

Zika virus (ZIKV), a mosquito-transmitted Flavivirus, emerged in the last decade causing serious diseases and affecting human health globally. Currently, no licensed vaccines or antivirals are available to combat ZIKV, although several vaccine candidates are in the pipeline. In recent years, the presence of non-canonical G-quadruplex (GQ) secondary structures in viral genomes has ignited significant attention as...

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PMID: 33575115
DOI: 10.1016/j.omtn.2020.12.030

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