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Eight-lncRNA signature of cervical cancer were identified by integrating DNA methylation, copy number variation and transcriptome data

8 Feb 2021

Abstract excerpt

BACKGROUND: Copy number variation (CNV) suggests genetic changes in malignant tumors. Abnormal expressions of long non-coding RNAs (lncRNAs) resulted from genomic and epigenetic abnormalities play a driving role in tumorigenesis of cervical cancer. However, the role of lncRNAs-related CNV in cervical cancer remained largely unclear. METHODS: The data of messenger RNAs (mRNAs), DNA methylation, and DNA copy number...

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PMID: 33557879
DOI: 10.1186/s12967-021-02705-9

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