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Article

Deregulated Immune Pathway Associated with Palbociclib Resistance in Preclinical Breast Cancer Models: Integrative Genomics and Transcriptomics.

Genes - 25 Jan 2021

Pandey Kamal, Lee Eunbyeol, Park Nahee, Hur Jin, Cho Young Bin, Katuwal Nar Bahadur, Kim Seung Ki, Lee Seung Ah, Kim Isaac, An Hee Jung, Hwang Sohyun, Moon Yong Wha

Abstract excerpt

Recently, cyclin-dependent kinase (CDK) 4/6 inhibitors have been widely used to treat advanced hormone receptor-positive breast cancer. Despite promising clinical outcomes, almost all patients eventually acquire resistance to CDK4/6 inhibitors. Here, we screened genes associated with palbociclib resistance through genomics and transcriptomics in preclinical breast cancer models. Palbociclib-resistant cells were...

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Identifiers

PMID: 33504001
DOI: 10.3390/genes12020159
PMCID: PMC7912104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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