Article
Clinical Phenotypes of Parkinson's Disease Associate with Distinct Gut Microbiota and Metabolome Enterotypes.
Biomolecules - 22 Jan 2021
Vascellari Sarah, Melis Marta, Palmas Vanessa, Pisanu Silvia, Serra Alessandra, Perra Daniela, Santoru Maria Laura, Oppo Valentina, Cusano Roberto, Uva Paolo, Atzori Luigi, Morelli Micaela, Cossu Giovanni, Manzin Aldo
Abstract excerpt
Parkinson's disease (PD) is a clinically heterogenic disorder characterized by distinct clinical entities. Most studies on motor deficits dichotomize PD into tremor dominant (TD) or non-tremor dominant (non-TD) with akinetic-rigid features (AR). Different pathophysiological mechanisms may affect the onset of motor manifestations. Recent studies have suggested that gut microbes may be involved in PD pathogenesis....
Topics
- Aged
- Diet
- Female
- Gas Chromatography-Mass Spectrometry
- Gastrointestinal Microbiome
- Humans
- Intestines
- Male
- Metabolome
- Middle Aged
- Oxidative Stress
- Parkinson Disease
- Phenotype