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Identification of key candidate biomarkers for severe influenza infection by integrated bioinformatical analysis and initial clinical validation

14 Jan 2021

Abstract excerpt

One of the key barriers for early identification and intervention of severe influenza cases is a lack of reliable immunologic indicators. In this study, we utilized differentially expressed genes screening incorporating weighted gene co-expression network analysis in one eligible influenza GEO data set (GSE111368) to identify hub genes associated with clinical severity. A total of 10 genes (PBI, MMP8, TCN1, RETN,...

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PMID: 33448094
DOI: 10.1111/jcmm.16275

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