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Article

POLG-associated ataxias can represent a substantial part of recessive and sporadic ataxias in adults.

Clinical neurology and neurosurgery - 1 Feb 2021

Nuzhnyi Evgenii, Seliverstov Yury, Klyushnikov Sergey, Krylova Tatiana, Tsygankova Polina, Bychkov Igor, Zakharova Ekaterina, Konovalov Rodion, Fedin Pavel, Abramycheva Natalia, Illarioshkin Sergey

Abstract excerpt

OBJECTIVE: We aimed to analyze prevalence, clinical, and genetic characteristics of the POLG-associated ataxias in a cohort of recessive and sporadic ataxias in adults with previously excluded acquired ataxias. METHODS: We did a retrospective analysis of the medical records of 74 patients older than 18 years referred to the Research Center of Neurology between 2012 and 2019 with progressive sporadic or autosomal...

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PMID: 33434755
DOI: 10.1016/j.clineuro.2020.106462

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