Article
Gut microbiota impact on the peripheral immune response in non-alcoholic fatty liver disease related hepatocellular carcinoma.
Nature communications - 8 Jan 2021
Behary Jason, Amorim Nadia, Jiang Xiao-Tao, Raposo Anita, Gong Lan, McGovern Emily, Ibrahim Ragy, Chu Francis, Stephens Carlie, Jebeili Hazem, Fragomeli Vincenzo, Koay Yen Chin, Jackson Miriam, O'Sullivan John, Weltman Martin, McCaughan Geoffrey, El-Omar Emad, Zekry Amany
Abstract excerpt
The gut microbiota is reported to modulate the immune response in hepatocellular carcinoma (HCC). Here, we employ metagenomic and metabolomic studies to characterise gut microbiota in patients with non-alcoholic fatty liver disease (NAFLD) related cirrhosis, with or without HCC, and evaluate its effect on the peripheral immune response in an ex vivo model. We find that dysbiosis characterises the microbiota of...
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