Article
Surgical Outcome and Histological Differences between Individuals with TGFBR1 and TGFBR2 Mutations in Loeys-Dietz Syndrome.
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia - 20 Feb 2021
Seike Yoshimasa, Matsuda Hitoshi, Ishibashi-Ueda Hatsue, Morisaki Hiroko, Morisaki Takayuki, Minatoya Kenji, Ogino Hitoshi
Abstract excerpt
PURPOSE: To identify differences in surgical outcomes between patients with transforming growth factor-beta receptor (TGFBR) 1 and TGFBR2 mutations in Loeys-Dietz syndrome (LDS). METHODS: In all, 22 LDS patients between 1998 and 2015 were divided into the two groups: TGFBR1 (n = 11) and TGFBR2 mutation (n = 11). RESULTS: The freedom from aortic reoperation was similar between the two groups (p = 0.19, log-rank)....
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