Article
Diversification of mammalian deltaviruses by host shifting.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 2021
Bergner Laura M, Orton Richard J, Broos Alice, Tello Carlos, Becker Daniel J, Carrera Jorge E, Patel Arvind H, Biek Roman, Streicker Daniel G
Abstract excerpt
Hepatitis delta virus (HDV) is an unusual RNA agent that replicates using host machinery but exploits hepatitis B virus (HBV) to mobilize its spread within and between hosts. In doing so, HDV enhances the virulence of HBV. How this seemingly improbable hyperparasitic lifestyle emerged is unknown, but it underpins the likelihood that HDV and related deltaviruses may alter other host-virus interactions. Here, we...
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