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Article

Distinctive metabolic profiles between Cystic Fibrosis mutational subclasses and lung function.

Metabolomics : Official journal of the Metabolomic Society - 4 Jan 2021

Masood Afshan, Jacob Minnie, Gu Xinyun, Abdel Jabar Mai, Benabdelkamel Hicham, Nizami Imran, Li Liang, Dasouki Majed, Abdel Rahman Anas M

Abstract excerpt

INTRODUCTION: Cystic fibrosis (CF) is a lethal multisystemic disease of a monogenic origin with numerous mutations. Functional defects in the cystic fibrosis transmembrane conductance receptor (CFTR) protein based on these mutations are categorised into distinct classes having different clinical presentations and disease severity. OBJECTIVES: The present study aimed to create a comprehensive metabolomic profile...

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PMID: 33394183
DOI: 10.1007/s11306-020-01760-5

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