Article
The possession of exon 2 or exon 3 variants in the MEFV gene promotes inflammasome activation in Japanese patients with familial Mediterranean fever with a heterozygous exon 10 mutation.
Clinical and experimental rheumatology - 1 Jan 2000
Endo Yushiro, Koga Tomohiro, Hara Kazusato, Furukawa Kaori, Agematsu Kazunaga, Yachie Akihiro, Masumoto Junya, Migita Kiyoshi, Kawakami Atsushi
Abstract excerpt
OBJECTIVES: The modification and pathogenesis of MEFV exon 2 or 3 variants in familial Mediterranean fever (FMF) remains unclear. We compared the clinical and laboratory characteristics between the coexistence and noncoexistence of MEFV exon 2 or 3 variants in patients with FMF that had a heterozygous MEFV exon 10 mutation. METHODS: We excluded patients with FMF that had two MEFV exon 10 mutations in one or more...
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