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Article

Can serial cerebral MRIs predict the neuronopathic phenotype of MPS II?

Journal of inherited metabolic disease - 1 May 2021

Vollebregt Audrey A M, Ebbink Berendine J, Rizopoulos Dimitris, Lequin Maarten H, Aarsen Femke K, Shapiro Elsa G, van der Ploeg Ans T, van den Hout Johanna M P

Abstract excerpt

OBJECTIVE: To advance the prediction of the neurocognitive development in MPS II patients by jointly analyzing MRI and neurocognitive data in mucopolysaccharidosis (MPS) II patients. METHODS: Cognitive ability scores (CAS) were obtained by neuropsychological testing. Cerebral MRIs were quantified using a disease-specific protocol. MRI sumscores were calculated for atrophy, white-matter abnormalities (WMA) and...

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Identifiers

PMID: 33330992
DOI: 10.1002/jimd.12342
PMCID: PMC8248480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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