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Co-expression Network Analysis Reveals Novel Genes Underlying Alzheimer’s Disease Pathogenesis

26 Nov 2020

Abstract excerpt

Background: The pathogenesis of Alzheimer’s disease (AD) remains to be elucidated. This study aimed to identify the hub genes in AD pathogenesis and determine their functions and pathways. Methods: A co-expression network for an AD gene dataset with 401 samples was constructed, and the AD status-related genes were screened. The hub genes of the network were identified and validated by an independent cohort. The...

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PMID: 33324198
DOI: 10.3389/fnagi.2020.605961

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