Immunophenotypic Characterization of Germ Cell Tumor-Derived Primitive Neuroectodermal Tumors: Evidence for Frequent Neuronal and/or Glial Differentiation.

doi:10.5858/arpa.2020-0352-OA

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Article

Immunophenotypic Characterization of Germ Cell Tumor-Derived Primitive Neuroectodermal Tumors: Evidence for Frequent Neuronal and/or Glial Differentiation.

Archives of pathology & laboratory medicine - 1 Aug 2021

Magers Martin J, Perrino Carmen M, Ulbright Thomas M, Idrees Muhammad T

Abstract excerpt

CONTEXT.—: Primitive neuroectodermal tumors (PNETs) may arise as a somatic-type malignancy in germ cell tumors. In this setting, most PNETs resemble those of the central nervous system and lack chromosome 22 translocations. However, description of the morphologic and differentiation spectrum of PNETs arising from germ cell tumors is lacking. OBJECTIVE.—: To investigate the morphologic and immunohistochemical...

Topics

Adolescent
Adult
Biomarkers, Tumor
Cell Differentiation
Chromogranin A
Glial Fibrillary Acidic Protein
Humans
Immunohistochemistry
Male
Middle Aged
Neoplasms, Germ Cell and Embryonal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neuroectodermal Tumors, Primitive, Peripheral

Neuroglia

Neurons

Phenotype

Predictive Value of Tests

S100 Proteins

SOXC Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 33290506
DOI: 10.5858/arpa.2020-0352-OA

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