Impact of vaginal microbiome communities on HIV antiretroviral-based pre-exposure prophylaxis (PrEP) drug metabolism

Abstract excerpt

Despite the efficacy of antiretroviral-based pre-exposure prophylactics (PrEP) in men who have sex with men, studies in women have produced widely varying outcomes. Recent evidence demonstrates that vaginal microbial communities are associated with increased HIV acquisition risk and may impact PrEP efficacy. Here, we investigate the mechanisms underlying how vaginal bacteria alter PrEP drug levels and impact HIV...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adolescent Sexual and Reproductive Health
• Share to HIV/AIDS Research and Interventions
• Share to Reproductive tract infections research