Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The X-linked acrogigantism-associated gene gpr101 is a regulator of early embryonic development and growth in zebrafish.

Molecular and cellular endocrinology - 15 Jan 2021

Trivellin Giampaolo, Tirosh Amit, Hernández-Ramírez Laura C, Gupta Tripti, Tsai-Morris Chon Hwa, Faucz Fabio R, Burgess Harold A, Feldman Benjamin, Stratakis Constantine A

Abstract excerpt

We recently described X-linked acrogigantism (X-LAG), a condition of early childhood-onset pituitary gigantism associated with microduplications of the GPR101 receptor. The expression of GPR101 in hyperplastic pituitary regions and tumors in X-LAG patients, and GPR101's normally transient pituitary expression during fetal development, suggest a role in the regulation of growth. Nevertheless, little is still known...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acromegaly
Share to Fertilization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrulation

Share to Genetic Diseases, X-Linked

Share to Gigantism

Share to Hypothalamus

Share to Zygote

Source

Open in PubMed Open full text

Identifiers

PMID: 33248229
DOI: 10.1016/j.mce.2020.111091
PMCID: PMC8771005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The X-linked acrogigantism-associated gene gpr101 is a regulator of early embryonic development and growth in zebrafish.PMID 33248229Read ↗

Characterization of GPR101 transcript structure and expression patternsSemantic proximity Read ↗

An orphan G-protein-coupled receptor causes human gigantism and/or acromegaly: Molecular biology and clinical correlations.Semantic proximity Read ↗

Gigantism: X-linked acrogigantism and GPR101 mutations.Semantic proximity Read ↗

Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation.Semantic proximity Read ↗

GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11.Semantic proximity Read ↗

Case report: Management of pediatric gigantism caused by the TADopathy, X-linked acrogigantismSemantic proximity Read ↗

Germline or somatic GPR101 duplication leads to X-linked acrogigantism: a clinico-pathological and genetic studySemantic proximity Read ↗

Congenital hypopituitarism in two brothers with a duplication of the 'acrogigantism gene' GPR101: clinical findings and review of the literature.Semantic proximity Read ↗

Non-penetrant Xq26.3 duplication involving the invariant TAD border: clinical evidence for the VGLL1 region as the GPR101 pituitary enhancer of X-linked acrogigantismSemantic proximity Read ↗

GPR101 Mutations are not a Frequent Cause of Congenital Isolated Growth Hormone Deficiency.Semantic proximity Read ↗

SomaticGPR101Duplication Causing X-Linked Acrogigantism (XLAG)—Diagnosis and ManagementSemantic proximity Read ↗

Chromatin conformation capture in the clinic: 4C-seq/HiC distinguishes pathogenic from neutral duplications at the GPR101 locusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.