Article
Genetic Variation in Toll-Like Receptor 5 and Colonization with Flagellated Bacterial Vaginosis-Associated Bacteria.
Infection and immunity - 16 Feb 2021
Dela Cruz Erin J, Fiedler Tina L, Liu Congzhou, Munch Matthew M, Kohler Christina M, Oot Antoinette R, Wallis Jacqueline M, Wang Junhui, Frishman Anna, Garcia Kristina, Wiser Andrew, Balkus Jennifer E, Srinivasan Sujatha, Golob Jonathan L, Sycuro Laura K, Marrazzo Jeanne M, Hawn Thomas R, Fredricks David N
Abstract excerpt
Bacterial vaginosis (BV) is a vaginal dysbiotic condition linked to negative gynecological and reproductive sequelae. Flagellated bacteria have been identified in women with BV, including Mobiluncus spp. and BV-associated bacterium-1 (BVAB1), an uncultivated, putatively flagellated species. The host response to flagellin mediated through Toll-like receptor 5 (TLR5) has not been explored in BV. Using independent...
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