Article
Establishment and application of a novel method based on single nucleotide polymorphism analysis for detecting β-globin gene cluster deletions.
Scientific reports - 26 Oct 2020
Hu Siqi, Zhan Wenli, Wang Jicheng, Xie Jia, Zhou Weiping, Yang Xiaohan, Zeng Yukun, Hu Tingting, Duan Lei, Chen Keyi, Du Li, Yin Aihua, Luo Mingyong
Abstract excerpt
β-Globin gene mutations reduce or terminate the production of beta globin chains, of which approximately 10% are large deletions within the β-globin gene cluster. Because gene deletion leads to loss of heterozygosity at single nucleotide polymorphism (SNP), a novel method for detecting β-globin gene cluster deletions based on SNP heterozygosity analysis was established in this study. The location range of SNPs...
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