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Article

TRIP13 promotes metastasis of colorectal cancer regardless of p53 and microsatellite instability status.

Molecular oncology - 1 Dec 2020

Agarwal Sumit, Behring Michael, Kim Hyung-Gyoon, Chandrashekar Darshan S, Chakravarthi Balabhadrapatruni V S K, Gupta Nirzari, Bajpai Prachi, Elkholy Amr, Al Diffalha Sameer, Datta Pran K, Heslin Martin J, Varambally Sooryanarayana, Manne Upender

Abstract excerpt

Overexpression of TRIP13, a member of the AAA-ATPase family, is linked with various cancers, but its role in metastasis is unknown in colorectal cancer (CRC). In the current study, we investigated the role TRIP13 in experimental metastasis and its involvement in regulation of WNT/β-catenin and EGFR signaling pathways. Evaluation of formalin-fixed paraffin-embedded (FFPE) and frozen tissues of adenomas and CRCs,...

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Identifiers

PMID: 33037736
DOI: 10.1002/1878-0261.12821
PMCID: PMC7718953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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