Article
Characterization of the Frmd7 Knock-Out Mice Generated by the EUCOMM/COMP Repository as a Model for Idiopathic Infantile Nystagmus (IIN).
Genes - 30 Sept 2020
Salman Ahmed, Hutton Samuel B, Newall Tutte, Scott Jennifer A, Griffiths Helen L, Lee Helena, Gomez-Nicola Diego, Lotery Andrew J, Self Jay E
Abstract excerpt
In this study, we seek to exclude other pathophysiological mechanisms by which Frmd7 knock-down may cause Idiopathic Infantile Nystagmus (IIN) using the Frmd7.tm1a and Frmd7.tm1b murine models. We used a combination of genetic, histological and visual function techniques to characterize the role of Frmd7 gene in IIN using a novel murine model for the disease. We demonstrate that the Frmd7.tm1b allele represents a...
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