Article
A multicentre analytical comparison study of inter-reader and inter-assay agreement of four programmed death-ligand 1 immunohistochemistry assays for scoring in triple-negative breast cancer.
Histopathology - 1 Mar 2021
Noske Aurelia, Ammann Johannes U, Wagner Daniel-Christoph, Denkert Carsten, Lebeau Annette, Sinn Peter, Kreipe Hans-Heinrich, Sommer Ulrich, Baretton Gustavo, Steiger Katja, Kiechle Marion, Hieke-Schulz Stefanie, Flores Mike, Roth Wilfried, Weichert Wilko
Abstract excerpt
AIMS: Studies in various cancer types have demonstrated discordance between results from different programmed death-ligand 1 (PD-L1) assays. Here, we compare the reproducibility and analytical concordance of four clinically developed assays for assessing PD-L1-positivity in tumour-infiltrating immune cells in the tumour area (PD-L1-IC-positivity) in triple-negative breast cancer (TNBC). METHODS AND RESULTS:...
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