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Influence of culture media on the derivation and phenotype of fetal-derived placental mesenchymal stem/stromal cells across gestation.

Placenta - 1 Nov 2020

Boss Anna L, Brooks Anna E S, Chamley Lawrence W, James Joanna L

Abstract excerpt

INTRODUCTION: Derivation of pure fetal placental mesenchymal stem/stromal cells (pMSCs) is key to understand their role in placental development. However, isolated pMSCs are often contaminated by maternal-derived decidual MSCs (dMSCs). EGM-2 medium promotes the derivation of term fetal pMSCs, but the extent of first-trimester maternal pMSC contamination remains unclear. Culture media can also affect MSC...

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PMID: 32932101
DOI: 10.1016/j.placenta.2020.09.002

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