Pasteurella multocida Pm0442 Affects Virulence Gene Expression and Targets TLR2 to Induce Inflammatory Responses

Abstract excerpt

Pasteurella multocida is an important pathogenic bacterium of domestic animals.Here, we found that Pm0442 was dramatically up-regulated in infected mice among 67 predicted lipoproteins of P. multocida serotype A CQ2 strain (PmCQ2), and Pm0442 deletion of PmCQ2 significantly decreased bacterial colonization and inflammatory responses in infectious mice, resulting in improved survival. Meanwhile, PmCQ2Δ0442 could...

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