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Circular HER2 RNA positive triple negative breast cancer is sensitive to Pertuzumab

11 Sept 2020

Abstract excerpt

BACKGROUND: Triple negative breast cancer (TNBC) remains the most challenging breast cancer subtype so far. Specific therapeutic approaches have rarely achieved clinical improvements in treatment of TNBC patients and effective molecular biomarkers are largely unknown. METHODS: We used paired TNBC samples and high throughput RNA sequencing to identify differentially expressed circRNAs. Sucrose gradient polysome...

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PMID: 32917240
DOI: 10.1186/s12943-020-01259-6

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