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Article

Vitamin D Receptor Polymorphisms in Sex-Frailty Paradox.

Nutrients - 5 Sept 2020

Arosio Beatrice, Guerini Franca Rosa, Costa Andrea Saul, Dicitore Alessandra, Ferri Evelyn, Mari Daniela, Torresani Erminio, Clerici Mario, Cesari Matteo, Vitale Giovanni

Abstract excerpt

The "male-female health-survival paradox" evidences that the survival advantage observed in women is linked to higher rates of disability and poor health status compared to men, a phenomenon also called the "sex-frailty paradox". The depletion of vitamin D seems to play a role in the fragilization of old persons, and genetic polymorphisms of the vitamin D receptor (VDR) gene seem to be involved in regulating the...

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PMID: 32899460
DOI: 10.3390/nu12092714
PMCID: PMC7551757

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