Efficacy and Safety of Sofosbuvir/Velpatasvir/Voxilaprevir for Hepatitis C Virus (HCV) NS5A-Inhibitor Experienced Patients With Difficult to Cure Characteristics.

doi:10.1093/cid/ciaa1318

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Efficacy and Safety of Sofosbuvir/Velpatasvir/Voxilaprevir for Hepatitis C Virus (HCV) NS5A-Inhibitor Experienced Patients With Difficult to Cure Characteristics.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 2 Nov 2021

Papaluca Timothy, Roberts Stuart K, Strasser Simone I, Stuart Katherine A, Farrell Geoffrey, MacQuillan Gerry, Dore Gregory J, Wade Amanda J, George Jacob, Hazeldine Simon, O'Beirne James, Wigg Alan, Fisher Leslie, McGarity Bruce, Sawhney Rohit, Sinclair Marie, Thomas James, Valiozis Ivan, Weltman Martin, Wilson Mark, Woodward Aidan, Ahlenstiel Golo, Haque Mazhar, Levy Miriam, Prewett Emily, Sievert William, Sood Siddharth, Tse Edmund, Valaydon Zina, Bowden Scott, Douglas Mark, New Kate, O'Keefe Jacinta, Hellard Margaret, Doyle Joseph, Stoove Mark, Thompson Alexander J

Abstract excerpt

BACKGROUND: In clinical trials, hepatitis C virus (HCV) salvage treatment with sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX) achieved an SVR12 rate of >95% in NS5A-experienced participants. Lower SVR12 rates have been reported in real-world studies, particularly for genotype (GT)3 infection and cirrhosis. We determined the efficacy and safety of SOF/VEL/VOX in a large real-world cohort. METHODS: We assessed...

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PMID: 32887983
DOI: 10.1093/cid/ciaa1318

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