A decrease in hepatitis C virus RNA to undetectable levels in chronic hepatitis C patients after PegIFNα + RVB or sofosbuvir + NS5A inhibitor treatment is associated with decreased insulin resistance and persistent oxidative stress.

doi:10.1007/s00705-020-04797-y

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Article

A decrease in hepatitis C virus RNA to undetectable levels in chronic hepatitis C patients after PegIFNα + RVB or sofosbuvir + NS5A inhibitor treatment is associated with decreased insulin resistance and persistent oxidative stress.

Archives of virology - 1 Dec 2020

Cázares-Cortazar Allison, Uribe-Noguez Luis A, Mata-Marín José Antonio, Gaytán-Martínez Jesús, de la Luz Martínez-Rodríguez María, Villavicencio-Ferrel Pedro Esteban, Chapararro-Sánchez Alberto, Mauss Stefan, Ocaña-Mondragón Alicia

Abstract excerpt

Oxidative stress (OS) and insulin resistance (IR) induced by hepatitis C virus (HCV) infection, are involved in the development of chronic hepatitis C (CHC) complications and progression to hepatocellular carcinoma. The aim of this study was to investigate the effect of pegylated interferon alpha (IFNα) + ribavirin (PegIFNα+RVB) or sofosbuvir + NS5A inhibitor (SOF+InNS5A) on IR and the components of OS. HCV was...

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PMID: 32885325
DOI: 10.1007/s00705-020-04797-y

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