Article
Recovery of the Sensitivity to Anti-PD-1 Antibody by Celecoxib in Lung Cancer.
Anticancer research - 1 Sept 2020
Kobayashi Kunihiko, Kaira Kyoichi, Kagamu Hiroshi
Abstract excerpt
BACKGROUND/AIM: Experimental studies have shown that celecoxib is related to the downregulation of Tregs and an increase in the therapeutic efficacy of PD-1 inhibitors; however, such effect has not been shown in human cancers. Our report confirmed the synergistic effect of celecoxib with a PD-1 inhibitor. CASE REPORT: A 57-year-old male with advanced pulmonary adenocarcinoma was treated with nivolumab monotherapy...
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