Article
Detection of p53 mutation and serum monitoring alert caused by Marek's disease virus in poultry.
BMC veterinary research - 24 Aug 2020
Zhang Huixia, Liu Mengda, Zhang Hui, Cao Shengliang, Li Yue, Jiang Shengnan, Song Yinuo, Liu Sidang
Abstract excerpt
BACKGROUND: Marek's disease (MD) is a chicken neoplastic disease, which brings huge economic losses to the global poultry industry. The wild type p53, a tumor suppressor gene, plays a key role in blocking cell cycle, promoting apoptosis, and maintaining the stability of the genome. However, the mutant p53 losses its tumor inhibitory role and become an oncogene when a mutation has happened. RESULTS: The mutation...
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