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Biomarkers of Osimertinib Response in Patients with Refractory, EGFR-T790M-positive Non-Small Cell Lung Cancer and Central Nervous System Metastases: The APOLLO Study.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2020

Xing Ligang, Pan Yueyin, Shi Yuankai, Shu Yongqian, Feng Jifeng, Li Wei, Cao Lejie, Wang Lifeng, Gu Wei, Song Yong, Xing Puyuan, Liu Yutao, Gao Wen, Cui Jiuwei, Hu Nana, Li Rutian, Bao Hua, Shao Yang, Yu Jinming

Abstract excerpt

PURPOSE: Dynamic biomarker monitoring may inform pathways for treating EGFR-T790M-positive non-small cell lung cancer (NSCLC) and central nervous system (CNS) metastases with osimertinib. This study aimed to determine the efficacy and safety of osimertinib for real-world patients with EGFR-T790M NSCLC and CNS metastases and to explore potential circulating biomarkers of therapeutic response. PATIENTS AND METHODS:...

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PMID: 32817079
DOI: 10.1158/1078-0432.CCR-20-2081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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