Article
Comprehensive analysis of the prognostic value and immune function of chemokine-CXC receptor family members in breast cancer.
International immunopharmacology - 1 Oct 2020
Lyu Lijuan, Zheng Yi, Hong Yun, Wang Meng, Deng Yujiao, Wu Ying, Xu Peng, Yang Si, Wang Shuqian, Yao Jia, Zhang Dai, Guo Yan, Lyu Jun, Dai Zhijun
Abstract excerpt
Recently, immune checkpoint inhibitors (ICIs) have been successfully used for treating melanoma. Unfortunately, many breast cancer (BC) patients show low response to ICIs due to the lack of infiltrating immune cells. Previous studies revealed that chemokine-CXC receptors (CXCRs) play a crucial role in leukocyte infiltration and promote cancer cell proliferation, migration, metastasis, and angiogenesis. However,...
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