A phase IV randomised, open-label pilot study to evaluate switching from protease-inhibitor based regimen to Bictegravir/Emtricitabine/Tenofovir Alafenamide single tablet regimen in Integrase inhibitor-naïve, virologically suppressed HIV-1 infected adults harbouring drug resistance mutations (PIBIK study): study protocol for a randomised trial.

doi:10.1186/s12879-020-05240-y

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A phase IV randomised, open-label pilot study to evaluate switching from protease-inhibitor based regimen to Bictegravir/Emtricitabine/Tenofovir Alafenamide single tablet regimen in Integrase inhibitor-naïve, virologically suppressed HIV-1 infected adults harbouring drug resistance mutations (PIBIK study): study protocol for a randomised trial.

BMC infectious diseases - 20 Jul 2020

Iwuji Collins C, Churchill Duncan, Bremner Stephen, Perry Nicky, To Ye, Lambert Debbie, Bruce Chloe, Waters Laura, Orkin Chloe, Geretti Anna Maria

Abstract excerpt

BACKGROUND: Currently recommended boosted protease-inhibitor (bPI) regimens may be associated with increased risk of cardiovascular or chronic kidney diseases; in addition, boosted regimens are particularly associated with drug-drug interactions. Since both cardiovascular and renal disease, and polypharmacy, are common in ageing people with HIV, there is a need for alternative efficacious regimens. bPI-based...

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PMID: 32689975
DOI: 10.1186/s12879-020-05240-y
PMCID: PMC7370264

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