A systems biology approach to understand gut microbiota and host metabolism in morbid obesity: design of the BARIA Longitudinal Cohort Study.

doi:10.1111/joim.13157

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Article

A systems biology approach to understand gut microbiota and host metabolism in morbid obesity: design of the BARIA Longitudinal Cohort Study.

Journal of internal medicine - 1 Mar 2021

Van Olden C C, Van de Laar A W, Meijnikman A S, Aydin O, Van Olst N, Hoozemans J B, De Brauw L M, Bruin S C, Acherman Y I Z, Verheij J, Pyykkö J E, Hagedoorn M, Sanderman R, Bosma N C, Tremaroli V, Lundqvist A, Olofsson L E, Herrema H, Lappa D, Hjorth S, Nielsen J, Schwartz T, Groen A K, Nieuwdorp M, Bäckhed F, Gerdes V E A

Abstract excerpt

INTRODUCTION: Prevalence of obesity and associated diseases, including type 2 diabetes mellitus, dyslipidaemia and non-alcoholic fatty liver disease (NAFLD), are increasing. Underlying mechanisms, especially in humans, are unclear. Bariatric surgery provides the unique opportunity to obtain biopsies and portal vein blood-samples. METHODS: The BARIA Study aims to assess how microbiota and their metabolites affect...

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PMID: 32640105
DOI: 10.1111/joim.13157
PMCID: PMC7984244

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