Article
The Study of Genetic Susceptibility and Mitochondrial Dysfunction in Mesial Temporal Lobe Epilepsy.
Molecular neurobiology - 1 Sept 2020
Yang Haiyan, Yin Fei, Gan Siyi, Pan Zou, Xiao Ting, Kessi Miriam, Yang Zhuangyi, Zhang Victor Wei, Wu Liwen
Abstract excerpt
The aim of this study is to investigate the mitochondrial dysfunction and pathogenic role of the mitochondrial genome in the progression of mesial temporal lobe epilepsy (MTLE) in vivo and in vitro. Mitochondrial DNA (mtDNA) and nuclear DNA were detected in the hippocampal samples and peripheral blood of patients with MTLE. Mitochondrial functions were detected in vivo and in vitro. In 20 patients with MTLE,...
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