Effect of Gut Microbiota and PNPLA3 rs738409 Variant on Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Youth.

doi:10.1210/clinem/dgaa382

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Article

Effect of Gut Microbiota and PNPLA3 rs738409 Variant on Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Youth.

The Journal of clinical endocrinology and metabolism - 1 Oct 2020

Monga Kravetz Ayesha, Testerman Todd, Galuppo Brittany, Graf Joerg, Pierpont Bridget, Siebel Stephan, Feinn Richard, Santoro Nicola

Abstract excerpt

CONTEXT: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease, affecting approximately 3 in 10 obese children worldwide. OBJECTIVE: We aimed to investigate the potential relationship between gut microbiota and NAFLD in obese youth, while considering the role of PNPLA3 rs738409, a strong genetic contributor to NAFLD. DESIGN: In this cross-sectional study, participants completed an...

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PMID: 32561908
DOI: 10.1210/clinem/dgaa382
PMCID: PMC7458486

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