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Article

Recurrent, Severe Aphthous Stomatitis and Mucosal Ulcers as Primary Manifestations of a Novel STAT1 Gain-of-Function Mutation.

Frontiers in immunology - 1 Jan 2020

Erdős Melinda, Jakobicz Eszter, Soltész Beáta, Tóth Beáta, Bata-Csörgő Zsuzsanna, Maródi László

Abstract excerpt

Chronic mucocutaneous candidiasis (CMC) characterized by persistent and recurrent Candida infection of the skin, nails, and the mucosa membranes has been proposed as the major infectious phenotype in patients with gain-of-function mutation of signal transducer and activator of transcription 1 (STAT1) 1. However, viral infections caused mostly by herpesviruses, and a broad range of autoimmune disorders may also be...

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Identifiers

PMID: 32547544
DOI: 10.3389/fimmu.2020.00967
PMCID: PMC7270203

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